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Year : 1987  |  Volume : 19  |  Issue : 3  |  Page : 174-178

Secondary structure of neuropeptide Y

Correspondence Address:
V Renugopalakrishnan

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Source of Support: None, Conflict of Interest: None

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1, The synthesis, biological activity and secondary structure of nenropeptide Y and its 4-Norleu analogue are discussed, The neuropeptides were synthesized by step-wise solid phase synthesis. 2. Secondary structures in aqueous solutions were investigated by CD and Raman spectroscopy. Chou-Fasman predictive algorithm were indicative of a N-terminal B turn segment followed by eithe u-helical or p-sheet sub-domain, which was consistent with experimental studies. 3. 4-Norleu-neuropeptide Y was more potent in inhibiting heart pace maker activity and coronary flow but less potent in inhibiting the cardiac contractility than native neuropeptide Y. The importance of the 4 positions in NPY in the cardiac activity is suggested. 4. A tentative secondary structural model for neuropeptide Y is proposed from the above studies.


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