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 RESEARCH PAPER
Year : 1987  |  Volume : 19  |  Issue : 2  |  Page : 94-99

Comparative biochemical and haematological study of enfenamic acid and some non-steroidal anti-inflammatory drugs



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SVV Sharma


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1. Comparative evaluation of enfenamic acid and few NSAID was done on biochemical parameters like blood sugar and uric acid and on baematological parameters like clotting time, platelet count, euglobulin clot lysis time and plsma fibrinogen content in rabbits. 2. Aspirin and ibuprofen per se induced hyperglycemia while tolmetin and indometbacin produced hypoglycaemic response.However, with enfenamic acid, hypoglycaemlc resposne was more marked in higher doses. Aspirin and tolmetin exhibited significant hypouricaemic effect, enfenamic acid and ibuprofen were less potent in this respect. 3. Thrombocytopenia and decrease in coagulation time was observed with aspirin, indometbacin, tolmetin and ibuprofen However, enfenamic acid failed to affect these para-meters. 4. Our study showed increased plasma fibrinogen content and euglobulin clot lysis time with aspirin, tolmetin and indomethacin while ibuprofen produced an increase in plasma fibrinogen content and had no effect on euglobulin clot lysis time; enfenamic acid had no effect on both the parameters.






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