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Year : 1987  |  Volume : 19  |  Issue : 2  |  Page : 85-93

Comparative evaluation of antiulcer effects of antidepressants

Correspondence Address:
V S Jaguste

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Source of Support: None, Conflict of Interest: None

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1. In an investigation of antiulcer potential of various antidepressants it was observed that trimipramine, nomifensine and mianserin (10 mg/kg i.p. 60 min prior) offered protection, against restraint stress (18 hour), aspirin (225 mg/kg, p.o. 4 hrs prior) and piroxicam (10 mg/kg i.p. 2 hrs prior) induced gastric ulcers. Iprindole, however, failed to offer significant protection. 2. Decrease in gastric mucosal sialic acid and hydroxyproline content, decrease in thymic and spienic weight and depletion of adrenal ascorbic acid on account of restraint stress were found to improve only with pretreatment with trimipramine, but not with iprindole. 3. Antiulcer effect of trimipramine, nomifensine and mianserin is likely to be on account of their property of increasing central norephtephrine which in turn improves gastric function.


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