IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1925 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1828    
    Printed84    
    Emailed3    
    PDF Downloaded144    
    Comments [Add]    

Recommend this journal

 

 SHORT COMMUNICATION
Year : 1987  |  Volume : 19  |  Issue : 2  |  Page : 140-144

Role of GABA in the anticonvulsant action of diazepam in albino mice



Correspondence Address:
Y V Rao


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

1. Intraperitoneal diazepam (0.75-2.0 mg/kg) produced significant anticonvulsant effect in albino mice against pentylenetetrazol (80 mg/kg, SC) induced convulsions. 2. Pretreatment with thiosemicarbazide (5 mglkg, ip, 1 h), reduced the anticonvulsant effect of a sub-maximal dose of diazepam (1 mg/kg, ip, 2 h) whereas sodium valproate and muscimol (0,2 mg/kg, ip, 0.5 h) enhanced the effect of subanticonvulsant dose of diazepam (0.5 mg/kg, ip, 2 h) indicating the role of endogenous GABA in the effect of diazepam. 3. Biochemical studies also showed an increrse in cerebral cortical level of GABA in diazepam (1 mg/kg, ip, 2 h) or sodium valproate and diazepam (0.5 mg/kg, ip, 2 h) pretreated animals. Thiosemicarbazide pretreatment prevented the enhancement of cerebral cortical GABA level by diazepam (1 mg/kg, ip, 2 h).






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow