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Year : 1987  |  Volume : 19  |  Issue : 2  |  Page : 140-144

Role of GABA in the anticonvulsant action of diazepam in albino mice

Correspondence Address:
Y V Rao

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Source of Support: None, Conflict of Interest: None

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1. Intraperitoneal diazepam (0.75-2.0 mg/kg) produced significant anticonvulsant effect in albino mice against pentylenetetrazol (80 mg/kg, SC) induced convulsions. 2. Pretreatment with thiosemicarbazide (5 mglkg, ip, 1 h), reduced the anticonvulsant effect of a sub-maximal dose of diazepam (1 mg/kg, ip, 2 h) whereas sodium valproate and muscimol (0,2 mg/kg, ip, 0.5 h) enhanced the effect of subanticonvulsant dose of diazepam (0.5 mg/kg, ip, 2 h) indicating the role of endogenous GABA in the effect of diazepam. 3. Biochemical studies also showed an increrse in cerebral cortical level of GABA in diazepam (1 mg/kg, ip, 2 h) or sodium valproate and diazepam (0.5 mg/kg, ip, 2 h) pretreated animals. Thiosemicarbazide pretreatment prevented the enhancement of cerebral cortical GABA level by diazepam (1 mg/kg, ip, 2 h).


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