| SHORT COMMUNICATION
|Year : 1987 | Volume
| Issue : 2 | Page : 134-139
Imipramine and d-tubocurarine interaction in vivo
BG Patel, MI Bhatt, KC Dave
1. A non-paralysing dose of d-tubocurarine (25 (g/kg) caused quicker onset of hind limb paralysis of a long duration in rats pretreated with imipramine (15,30 mg/kg). Pretreatment with imipramine (10,15,30 mg/kg) in rabbits reduced the minimum effective head drop dose of d-tubocurarine.
2. Potentiating effect persisted upto 24 h, and total recovery from the effect appeared after 48 h, of imipramine (30 mg/kg) pretreatment,
3. It is suggested that the potentiation of the action of d-tubocurarine by imipramine may be of clinical importance, in patients receiving imipramine.
B G Patel
Source of Support: None, Conflict of Interest: None