IPSIndian Journal of Pharmacology
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 SHORT COMMUNICATION
Year : 1987  |  Volume : 19  |  Issue : 2  |  Page : 130-133

Effect of scoparone on tissue catecholamine content


Correspondence Address:
M L Sharma


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Source of Support: None, Conflict of Interest: None


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1. The effect of scoparone on catecholamine content of adrenal glands, spleen, brain and intestinal tissues of rats was investigated. 2. A single oral dose of scoparone (100 mg/kg-1) produced reduction of catecholamine content of adrenal glands and spleen without affecting that of brain, heart and small intestines. 3. On repeated oral administration also, it lowered the catecholamine content of the adrenal glands but not that of brain. 4. The catecholamine lowering effect appeared within 6h, and was maximum at 24 h. The hypotensive and tranquillosedative effects of scoparone appeared within 15-20 min after oral administration and lasted for 4-6 h.The pharmacological effects of scoparone, therefore, appear to be independent of its catecholamine depleting action.






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