IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 114 
Small font sizeDefault font sizeIncrease font size
Navigate Here
    Next article
    Previous article
    Table of Contents

Resource Links
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1351    
    Printed88    
    Emailed1    
    PDF Downloaded111    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1987  |  Volume : 19  |  Issue : 2  |  Page : 108-116

Effect of chronic lead toxicity on the sensitivity of anococcygeus muscle of rat



Correspondence Address:
R S Shah


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

1. The present investigation was undertaken to study the effects of chronic lead toxicity on the sensitivity of rat anococcygeus muscle to various agonists. 2. Treatment of rats with lead acetate (6.5 mg/kg/day, i,p. for 21 days) resulted in significant elevation of blood level and ( -aminolevulnic acid in urine ( ( -ALA-U). 3. The anococcygeus muscle isolated from lead treated rats exhibited supersensitivity to noradrenaline, dopamine, carbachol and 5-hydroxytryptamine. 4. Deprivation of Cat-t from the bathing medium did not alter significantly the responses to these agonists, however the supersensitivity was completely abolished in anococcy-geus muscle preparations obtained from lead treated animals. 5. The supersensitivity to these agonists was maintained in lead treated preparations bathed in medium containing high Ca++. 6. Ca Cl2 produced a dose depeodent contraction in the presence of sub-threshold dose of various agonists. These responses were significantly increased in lead treated preparations. 7. Our data indicate that chronic lead toxicity produces supersensitivity to various agonists in rat anococcygeus muscle.The mechanism of this supersensitivity may be related to an increased availability of calcium and/or increased sensitivity to the calcium of the tissues.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow