| RESEARCH PAPER |
|
| Year : 1987 | Volume
: 19
| Issue : 1 | Page : 44-48 |
Local anaesthetic activity of 9-alkylamino-1,2,3,4,-tetrahydroacridines: structure-activity relationship study
SN Rastogi, GK Patnaik, BN Dhawan
Correspondence Address:
S N Rastogi
 Source of Support: None, Conflict of Interest: None  | Check |
1. A series of 9-alkylamino-1, 2, 3, 4-tetrahydroacridines and analogues were synthesized and tested for local ansesthetic activity in rabbits and guinea pigs.
2. 9-n-Heptylamino-1, 2, 3, 4-tetrahydroacridines showed the maximum activity and were more potent than lignocaine.
3. The local anaesthetic activity seems to be partly influenced by the lipophilicity of the compounds.
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