| RESEARCH PAPER
|Year : 1987 | Volume
| Issue : 1 | Page : 44-48
Local anaesthetic activity of 9-alkylamino-1,2,3,4,-tetrahydroacridines: structure-activity relationship study
SN Rastogi, GK Patnaik, BN Dhawan
1. A series of 9-alkylamino-1, 2, 3, 4-tetrahydroacridines and analogues were synthesized and tested for local ansesthetic activity in rabbits and guinea pigs.
2. 9-n-Heptylamino-1, 2, 3, 4-tetrahydroacridines showed the maximum activity and were more potent than lignocaine.
3. The local anaesthetic activity seems to be partly influenced by the lipophilicity of the compounds.
S N Rastogi
Source of Support: None, Conflict of Interest: None