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 RESEARCH PAPER
Year : 1987  |  Volume : 19  |  Issue : 1  |  Page : 19-25

Effect of chronic treatment of estrogen and progesterone on histamine receptor sensitivity in guinea-pig uterus



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D D Desai


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1. In the present investigation the influence of estrogen and progesterone on the histamine induced responses in guinea pig uterus was studied. 2. The responses to histamine were significantly decreased in preparations pretreated with estrogen (pD2=4.75) or progesterone (pD2=5.27). 3. Blockade of responses to histamine by mepyramine after estrogen (pA2=8.65) and progesterone pretreatment (pA2=9.1 1) were significantly less than the control. 4. Dose dependant contractile responses of guinea-pig uterus were obtained with 2 - (2 pyridyl) ethylamine (pO2=5.95) which decreased after estrogen pretreatment (pD2=4 .35) or progesterone pretreatment (pD2=4.87). 5. The data suggest a decrease in H1 receptor sensitivity in guinea pig uterus after estrogen or progesterone pretreatment.






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