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 RESEARCH PAPER
Year : 1986  |  Volume : 18  |  Issue : 4  |  Page : 230-234

Effect of a few beta-blockers on the arrhythmogenic action of ouabain in guinea pigs



Correspondence Address:
R M Tripathi


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1. Cardiac arrhythmias were produced by slow intravenous infusion of ouabain in guinea pigs and doses of ouabain required for the production of early arrhythmia, ventricular fibrillation and cardiac arrest were calculated. 2. A comparison was made between control group and the animals treated with the beta-blockers having diverse pharmacological profiles, at different dose levels. 3. The results indicate that all the beta adrenergic blockers used i.e. propranolol, labetalol, practolol and sotalol are effective against ouabain induced cardiac arrhythmias. Propranolol with membrane stabilizing activity and labetalol with alpha, blockingactivityare superior to practolol and sotalol in this model of arrhythmia.






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