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Year : 1986  |  Volume : 18  |  Issue : 4  |  Page : 211-214

Screening of Phyllanthus niruri Linn.and ricinus communis Linn. on alcohol-induced liver cell damage in non-hepatectomised and partially hepatectomised rats

Correspondence Address:
S S Agarwal

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Source of Support: None, Conflict of Interest: None

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1. A new model of short duration for inducing hepatotoxicity in rats has been developed by administering Tohfa' a country made liquor (28.5% of Ethanol) to partially hepatectomized (65-70%) rats orally, daily for ten days. 2. Fatty changes were taken as an index of hepatotoxicity because other changes namely fibrosis and cirrhosis cannot be produced in rats. 3. Biochemical and histopathological studies revealed that 50% alcoholic extract of roots and leaves of Phyllanthus niruri Linn. (PN), commonly known as Jaramala in Hindi, has got hepatoprotective effect on alcohol induced liver cell damage in non-hepatectomized and partially hepatectomized rats . 4. The root extract of PN was found to be more effective hepatoprotective agent than the leaves extract. 5. 50% alcoholic extract of leaves of Ricinus communis Linn. (RC), commonly known as Arand in Hindi, did not show any significant hepatoprotective activity.


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