IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 273 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1405    
    Printed74    
    Emailed3    
    PDF Downloaded76    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1986  |  Volume : 18  |  Issue : 4  |  Page : 207-210

Histamine induces reflex hypotension through gut receptors in rabbits



Correspondence Address:
V Radhakrishnan


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

1. Application of 200 (g dose of histamine to the serosal surface of stomach or intestine in urethane anaesthetized rabbits produced within l-3 sec, a significant fall in blood pressure without affecting the heart rate and respiration. 2. This effect persisted even after intravenous administration of cimetidine (2 mg/kg) ruling out the possibility of a direct action of histamine on H2 receptors of vascular smooth muscles. 3. The response was effectively blocked by pretreatment of the serosa with mepyramine, but not by cimetidine. Application of 2-methyl histamine to gut serosa produced a similar fall in blood pressure as produced by histamine, and application of 4-methyl histamine did not produce any significant change. 4. The effect of serosal application of histamine was not affected by bilateral abdominal vagotomy, but was totally abolished by splanchnicotomy. 5. These results indicate that stimulation of H1- receptors of the gut leads to a reflex fall in blood pressure mediated through the splanchnic afferents. As the response is not associated with any change in heart rate, a reduction in sympathetic efferent discharge leading to vasodilation could possibly be the cause for hypotension.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow