IPSIndian Journal of Pharmacology
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 RESEARCH PAPER
Year : 1986  |  Volume : 18  |  Issue : 4  |  Page : 202-206

Effect of clonidine on regional circulation in cat



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A Gulati


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1. The effect of clonidine (10 (g/Kg iv) on blood flow and vascular resistance in various organs and tissues of anesthetised cats was studied using the radioactive microsphere technique. 2. Clonidine produced hypotension, bradycardia, increased cardiac output and stroke volume, decreased left ventricular work and total peripheral resistance. The peak effect came after 30 min when significant changes were also noted in brain and myocardial blood supply. 3. In the brain, increased blood flow and decreased vascular resistance was obtained in medulla and thalamus and reverse changes occured in the caudate nucleus and the pons. In cerebellum only blood flow decreased while in cerebral cortex vascular resistance decreased without change in the blood flow. 4. The blood flow to all regions of the heart decreased particularly in subendocardial tissue but vascular resistance was unaffected.






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