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Year : 1986  |  Volume : 18  |  Issue : 3  |  Page : 158-162

Effects of levamisole on isolated anococcygeus muscle of rat

Correspondence Address:
K K Shah

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Source of Support: None, Conflict of Interest: None

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1. Effects of levamisole (Lev) were investigated on the rat isolated anococcygeus muscle. 2. Lev in low concentration (2.8x10-5 M) per se elicited no contractile effect on the Prepration but potentiated (P<0.05) the responses to noradrenaline (3.13x10-8 M to 9.39x10-7 M). 3. Higher concentrations of lev (4.15x10-5 M to 1.24x10-3 M) elicited dose-related contractile responses, which were blocked by phentolamine (3.26xlO-8M). 4. In reserpinized tissue the dose-response curve of lev was inhibited ( p<0.01) 5. Pretreatment with cocaine (8.83x10-6M and 2.94x10-5 M), normetanephrine (5.46 x lO-5 M), nialamide (3.35 X $a1 10-5M) or tropolone (4.1 X 1O-4M) and combination of nialamide and tropolone significantly (p


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