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Year : 1986  |  Volume : 18  |  Issue : 3  |  Page : 154-157

Vitamin A reverses the wound-healing suppressant effect of cyclophosphamide

Correspondence Address:
S S Raju

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Source of Support: None, Conflict of Interest: None

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1. Vitamin A has been reported to be an antineoplastic and also claimed to promote wound healing. 2. Vitamin A effects on cyclophosphamide induced suppression of healing was investigated in two wound models, viz: resutured incision and full thickness excision wound in rats. 3. Cyclophosphamide (60 mg/kg ipon3rd wounding day)significantly reduced tensile strength (incision wounds), extended epithelization period, suppressed wound contraction and increased scar size (excision wound) 4. Vitamin A (5000 IU, sc altrenate day) reversed the above deffects of cyclophosphamide. 5. In excision wounds the vitamin promoted epithelization and contraction even in the absence of cyclophosphamide suppression. 6. It is concluded that vitamin A reverses wound-healing suppressant effect of cyclophosphamide and also promotes normally progressing healing of excision wounds.


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