IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1851 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1903    
    Printed99    
    Emailed0    
    PDF Downloaded140    
    Comments [Add]    

Recommend this journal

 

 RESEARCH PAPER
Year : 1986  |  Volume : 18  |  Issue : 3  |  Page : 144-148

Correlation of serum total and free phenytoin levels with drug intake and seizure control



Correspondence Address:
S N Ahmad


Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

1. Sera of 92 epileptic patients, receiving phenytoin (3-7mg/kg/per day) alone/ in combination with phenobarbitone (1-2 mg/kg/day), were analysed for total and free phenytoin spectrophotometrically. 2. The respective means of total and free phenytoin in the phenytoin group were not significantly different from the phenytoin plus phenobarbitone group. 3. The relationshp between total and free phenytoin, in all patients, was curvilinear i.e. biphasic. The proportion of free phenytoin in patients with total phenytoin <20(g/ml was significantly (p<0.01) higher than those with total phenytoin <20 (g/ml 4. Compared to uncontrolled patients the controlled patients without toxicity showed no statistical differences in mean levels of total and free phenytoin; significantly higher proportion of free drug and a tendency to maintain higher levels of both free and total drug at a given dose, and a significant rise in these levels with dosage increment. 5. The mean total and free phenytoin levels in patients who developed toxicity were higher than the uncontrolled as well as controlled patients without toxicity.






[PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow