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Year : 1986  |  Volume : 18  |  Issue : 2  |  Page : 89-94

Some neuropharmacological actions of 3-methyl-5-phenyl-(4 -methyl)quinolenodiazepine

Correspondence Address:
Z A Wafai

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Source of Support: None, Conflict of Interest: None

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1. The compound 3-methyl-5-phenyl-(4'methyl)-quinolenodiazepine, a newly synthe-sised molecule combines a quinolene ring with diazepine heterocyclic ring, both reportedly having CNS depressant properties, was investigated in the present study for CNS activity in rats and mice. 2. The compound possesses weak anxiolytic properties, weak appetite suppressant properties and mild central muscle relaxant properties. These effects occur at a dose which does not reduce spontaneous motor activity or cause sedation/hypnosis. 3. The LD50 of the compound is 250 ( 18.97 mg.kg-1.


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