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Year : 1986  |  Volume : 18  |  Issue : 2  |  Page : 78-83

Pharmacodynamic studies on Kalanchoe integra-an indigenous plant

Correspondence Address:
R K Varma

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Source of Support: None, Conflict of Interest: None

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1. The aqueous extract of the leaf of Kalanchoe integra (KI) produced CNS depressant effect. It affected forced co-ordinated motor activity, decreased the spontaneous motor activity, increased pentoobarbitone sleeping time and impaired conditioned avoidance response. 2. It produced marked hypotensive effect in anaesthetised dog, which was not blocked by either atropine or promethazine and negative inotropic effect on intact dog heart which probably was responsible for the hypotensive action. 3. KI produced dose-dependent inhibition of the contractions induced by acetylcholine, histamine and barium on guinea pig ileum and was devoid of any effect on the frog rectus abdominis muscle. 4. A positive inotrpic effect was observed on isolated frog heart which was not blocked by either propranolol or promethazine.


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