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Year : 1986  |  Volume : 18  |  Issue : 2  |  Page : 104-106

Plasma prostaglandin levels in febrile illnesses

Correspondence Address:
K P Gupta

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Source of Support: None, Conflict of Interest: None

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1. Plasma prostaglandin levels were estimated in 13 normal individuals and in 35 patients suffering from febrile illnesses due to short viral fever, viral hepatitis, amoebic liver abscess, transfusion reaction, lobar pneumonia, enteric fever, acute malarial fever and pulmonary tuberculosis. 2. In all cases of febrile illnesses there was 2-5 fold increase in plasma prostaglandin levels which again came down to normal after oral administration of paracetamol or when the fever subsided itself. 3. The findings suggest that there is increased synthesis/release of prostaglandins in the blood which crosses the blood brain barrier to act upon the pre-optic anterior hypothalamus to produce fever.


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