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Year : 1986  |  Volume : 18  |  Issue : 1  |  Page : 9-13

Biphasic effects of dopamine agonists on haloperiodol induced catalepsy

Correspondence Address:
P C Dandiya

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Source of Support: None, Conflict of Interest: None

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1. At low doses, dopamine agonists, apomorphine (0.25-0.5 mg/kg), lisuride (0.001-0.01 mg/kg) and pergolide (0.005-0.01 mg/kg) lowered the latency period of haloperidol (0.25 mg/kg) induced catalepsy in rats. However, when higher doses were given, apomorphine (5.0-10.0 mg/kg) lisuride (0.05-0.1 mg/kg) and pergolide (0.25-1.0 mg/kg) increased the latency period. 2. Pretreatment with low doses of haloperidol(0.025-0.05mg/kg) partially prevented the lowering of the latency period due to low doses of dopamine agonists. 3. These findings tend to provide one more evidence to confirm that more than one group of dopamine receptors are involved in this typical biphasic response.


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