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Year : 1985  |  Volume : 17  |  Issue : 4  |  Page : 210-213

Role of adrenoceptors in adrenaline induced hyperglycaemia in cats

Correspondence Address:
V N Dadkar

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Source of Support: None, Conflict of Interest: None

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1. In the present study, specific alpha-1 antagonist prazosin, alpha-2 antagonist yohimbine and beta adrenergic antagonist propranolol were used either alone or in combination to evaluate their effect on adrenaline induced hyperglycaemic response. 2. It was observed that pretreatment with each one of these agents could bring about significant inhibition of hyperglycemic effect. 3. However, almost complete inhibition of hyperglycaemic effect could be achieved only when either alpha-1 antagonist or alpha-2 antagonist were combined with beta adrenergic antagonist. Combined therapy using alpha-1 antagonist and alpha-2 antagonist did not show any synergistic action. 4. The results suggested that both alpha and beta receptors are involved in hyperglycemic effect but role of alpha-1 and alpha-2 receptors is more or less same.


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