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Year : 1985  |  Volume : 17  |  Issue : 4  |  Page : 192-196

Cardiovascular effects of central and peripheral administration of dopamine in hypertensive and normotensive rats

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1. Effects of intracerebroventricular (i.c.v.) and intravenous (i.v.) injection of dopamine (DA), 12.5- 400 (g/kg on blood pressure (BP) and heart rate (HR) were studied in conscious spontaneously hypertensive rats (SHR) and compared with 2 other models of hypertension and their normotensive controls. 2. Blood pressure decreased significantly in SHR after i.c.v. DA when compared to hypertensive and normotensive controls in a dose-related manner. 3. HR decreased in all cases except that at a dose of more than 25(gDA/kg in SHR an increase was seen. 4. The results support the hypothesis for a central dopaminergic insufficiency in SHR.


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