| RESEARCH PAPER |
|
| Year : 1985 | Volume
: 17
| Issue : 4 | Page : 192-196 |
Cardiovascular effects of central and peripheral administration of dopamine in hypertensive and normotensive rats
JSL Mok, ML Kong, JS Hutchinson
Correspondence Address:
JSL Mok
 Source of Support: None, Conflict of Interest: None  | Check |
1. Effects of intracerebroventricular (i.c.v.) and intravenous (i.v.) injection of dopamine (DA), 12.5- 400 (g/kg on blood pressure (BP) and heart rate (HR) were studied in conscious spontaneously hypertensive rats (SHR) and compared with 2 other models of hypertension and their normotensive controls.
2. Blood pressure decreased significantly in SHR after i.c.v. DA when compared to hypertensive and normotensive controls in a dose-related manner.
3. HR decreased in all cases except that at a dose of more than 25(gDA/kg in SHR an increase was seen.
4. The results support the hypothesis for a central dopaminergic insufficiency in SHR.
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