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Year : 1985  |  Volume : 17  |  Issue : 3  |  Page : 158-164

On the effect of some anti-inflammatory drugs on serum half-life and hypoglycaemic response of tolbutamide

Correspondence Address:
H Kumar

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Source of Support: None, Conflict of Interest: None

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1. The effect of non-steroidal anti-inflammatory agents like aspirin, tromaril and tolmetin on tolbutamide-induced hypoglycaemia in normal and alloxan-induced diabetic rabbits was studied. In order to evaluate the mechanism of interaction the effect of non-steroidal anti-inflammatory agents was also observed on the blood glucose level aswell as on serum tolbutamide concentration. 2. Single dose concurrent administration and 7 days continued treatment with aspirin and tolmetin enhanced tolbutamide-induced hypoglycaemia. However, a decrease in serum tolbutamide level was observed when given concurrently with single dose of anti-inflammatory drugs. Tromaril failed to affect tolbutamide hypoglycaemia and serum concentration of tolbutamide both in normal as well as in diabetic rabbits. 3. It is reasonable to conclude that aspirin and tolmetin possess interacting potentiality probably by virtue of their intrinsic hypoglycaemic activity and plasma protein binding property.


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