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Year : 1985  |  Volume : 17  |  Issue : 3  |  Page : 155-157

Local anaesthetic activity of some parasubstituted acetophenone mannich bases

Correspondence Address:
S C Chaturvedi

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Source of Support: None, Conflict of Interest: None

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1. Twenty five Mannich bases of para substituted acetophenones were synthesized and tested for local anaesthetic activity in rabbits and guineapigs. 2 All the compounds of dibenzyl series showed significant surface and infiltration anaesthetic activity. 3. In the piperidine series only compound (-piperidinoethyl p-chlorophenyl ketone HCI showed local anaesthetic activity. This compound did not possess any local irritant effect.


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