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Year : 1985  |  Volume : 17  |  Issue : 3  |  Page : 152-154

Endogenous sex steroids and uterine responsiveness to ecbolics in normal and high risk pregnancy

Correspondence Address:
S R Chowdhary

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Source of Support: None, Conflict of Interest: None

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1. The effect of various ecbolics was studied on isolated human myometrial strips obtained at caesarian section from normal and high risk pregnancy cases. 2. Oxytocin was found to be the most potent ecbolic and acetylcholine the least active. The activity of the other agents tested was PGEI>PGE >PGF -(>ergometrine>histamine >serotonin. 3. Further a possibility of greater sensitivity of uterus to oxytocin in the pre-oclamptic toxaemia and bad obstretic cases was indicated, it also appeared that with decreased ratio between the serum progesterone and oestradiol, within a particular group of patients, the myometrium was found to be more sensitive to oxytocin.


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