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Year : 1985  |  Volume : 17  |  Issue : 3  |  Page : 144-147

Serum and cerebrospinal fluid levels of phenytoin in epileptic patients in relation to control of seizures

Correspondence Address:
N F Jaffery

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Source of Support: None, Conflict of Interest: None

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1. In 33 epileptic patients on phenytoin monotherapy. the CSF levels of the drug constituted 12.5( 5% (range 5.4 to 23%) of the serum levels. 2. The mean serum levels of the drug (13.356 (g/ml) in controlled patients (17) were not significantly different from the levels in uncontrolled patients (11). The mean CSF levels in uncontrolled patients (0.92(O.32) were significantly lower (p<0.001) than those in controlled patients (1.49(0.59). 3. In 5 patients who developed toxicity, the serum (27.3 ( 10.6) as well CSF (5.3 ( 1.8) levels of phenytoin were significantly higher than those of uncontrolled and controlled (without toxicity) patients.


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