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Year : 1985  |  Volume : 17  |  Issue : 3  |  Page : 132-135

Estrogen induced alterations in the sensitivity of dopamine receptors In rat

Correspondence Address:
P Tandon

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Source of Support: None, Conflict of Interest: None

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1. Effect of ethinyl estradiol (Lynoral) on 3H-spiroperidol binding has been studied in hypothalamic and corpus striatal regions of the brain after acute and subchronic exposure. 2 Ethinyl estradiol (10(g/kg) after 3 consecutive doses (acute) showed significant increase in 3H-spiroperidol) binding only in hypothalamic membrane without affecting the corpus striatal membrane. 3. A significant increase in 3H-spiroperidol binding was observed in caudate and hypothalamic membrane in the animals exposed to same dose of estradiol for 21 consecutive days (subchronic). 4. The results suggest that ethinyl estradiol effects dopamine receptor sensitivity in brain regions.


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