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Year : 1985  |  Volume : 17  |  Issue : 2  |  Page : 98-102

Neuroleptic therapy and antihistaminic drugs: a pharmacological study

Correspondence Address:
T J Hemnani

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Source of Support: None, Conflict of Interest: None

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(1) The antipsychotic effects of chlorpromazine have been potentiated by mepyramine and pheniramine, unaffected by diphenhydramine and meclizine, while it is antagonised by promethazine. (2) Regarding extrapyramidal effects, promethazine, diphenhydramine and mepyramine have strong antagonising effect as compared to pheniramine and meclizine. (3) Comparison of risk-benefit ratio, suggest that during neuroleptic therapy, the prophylactic use of promethazine has harmful effect, diphenhydramine and meclizine have no effect, while mepyramine and pheniramine have a beneficial effect.


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