| SHORT COMMUNICATION
|Year : 1985 | Volume
| Issue : 2 | Page : 113-115
Anti-inflammatory activity of substituted guanidine hydrochlorides
Saxena Archna, Aron Rina, SC Mehra, SK Tandan
1. Twelve different substituted guanidines were prepared by the condensation of different heterocyclic moieties with different aryl cyanamides.
2. Compounds were screened for anti-inflammatory activity and compared with standard drug phenylbutazone.
3. Ten compounds showed significant anti-inflammatory activity and compound IV, N-P-anisyl-N'-5-phenyl-1,3,4-oxadiazol-2-yl guanidine hydrochloride, was the most potent In carrageenin-induced oedema.
Source of Support: None, Conflict of Interest: None