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Year : 1985  |  Volume : 17  |  Issue : 2  |  Page : 113-115

Anti-inflammatory activity of substituted guanidine hydrochlorides

Correspondence Address:
Saxena Archna

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Source of Support: None, Conflict of Interest: None

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1. Twelve different substituted guanidines were prepared by the condensation of different heterocyclic moieties with different aryl cyanamides. 2. Compounds were screened for anti-inflammatory activity and compared with standard drug phenylbutazone. 3. Ten compounds showed significant anti-inflammatory activity and compound IV, N-P-anisyl-N'-5-phenyl-1,3,4-oxadiazol-2-yl guanidine hydrochloride, was the most potent In carrageenin-induced oedema.


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