| RESEARCH PAPER
|Year : 1985 | Volume
| Issue : 2 | Page : 108-112
Behavioural evidence for direct stimulation of rat brain 5-Hydroxytryptamine receptors by ergometrine
TR Bapat, VP Gada, NV Nandal, JJ Balsara, AG Chandorkar
1. Ergometrine produced a behavioural syndrome in the rat which was characterized by head and body shakes, lateral head weaving, forepaw treading, hindlimb abduction and Straub tail.
2. Pretreatment with 5-HT receptor antagonists, cyproheptadine and methysergide, significantly decreased the intensity of the behavioural syndrome produced by ergometrine.
3. Pretreatment with p-chlorophenylalanine and clomipramine significantly decreased the intensity of the behavioural syndromes induced by fenfluramine and p-chloramphetamine but had no significant effect on the intensity of the behavioural syndrome produced by ergometrine.
4. The results indicate that ergometrine produces the 5-HT mediated behavioural syndrome by directly stimulating the central 5-HT receptors.
T R Bapat
Source of Support: None, Conflict of Interest: None