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Year : 1985  |  Volume : 17  |  Issue : 2  |  Page : 103-107

Effect of antiarrhythmic drugs on ventricular fibrillation threshold and cardiac stores of norepinephrine in the cat.

Correspondence Address:
M Pande

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Source of Support: None, Conflict of Interest: None

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1. Comparative evaluation of the effect of anti-arrhythmic drugs on ventricular fibrillation threshold (VFT) and on theconcentration of norepinephrine (NE) in the different parts of the myocardium of the cat has been undertaken. 2. In pentobarbitone anaesthetised cats fibrillation induced by electrical stimulation (ES.) of the left ventricle caused reduction of NE in the heart. 3. Quinidine and disopyramide, the membrane stabilizers; lidocaine, a local anaesthetic; adrenergic receptor blockers like phenoxybenzamineand propranoloI, and verapamil, a calcium antagonist, caused bradycardia, hypotension and decrease in NE content. 4. Pretreatment with quinidine, disopyramideand lidocaine inhibited further release of NE from the myocardium following E.S. and significantly raised VFT. 5. Phenoxybenzamine (10 mg/kg), propranolol (5 mg/kg) and verapamil (1 mg/kg) did not inhibit the release of NE. Phenoxybenzamine provided protection against ventricular fibrillation whereas propranolol and verapamil failed. 6. The results suggest the involvement of ( adrenergic receptor as a contributing factor in the onset of ventricular fibrillation induced by E.S.


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