| RESEARCH PAPER
|Year : 1985 | Volume
| Issue : 1 | Page : 51-54
On the mechanism of gastric ulcerations induced by ibuprofen in rats
B Gupta, KK Saxena, RK Srivastava, DN Prasad
1. Ibuprofen in doses of 100 and 200 mg/kg, p.o. for six consecutive days produced gastric ulceration in albino rats.
2. An increase in acid output seems to be responsible for this ulcerogenic response.
3. Pretreatment with adrenergic, cholinergic, tryptaminergic and histaminergic (H1) receptor antagonists provided partial protection, while metiamide pretreatment afforded almost complete protection and reduced the acidity.
4. It appears that histamine H2 receptors are predominently involved in the ulcerogenicity of ibuprofen.
Source of Support: None, Conflict of Interest: None