| RESEARCH PAPER
|Year : 1985 | Volume
| Issue : 1 | Page : 42-50
Effect of hypovolemia and hypertonicity on the ultrastructure and function of neurohypophysis in the mastomys natalensis
K Chakravarty, SC Maitra, AC Shipstone, K Kar
1. The relative effects of blood volume contraction and hypertonicity on the vasopressin content and ultrastructure of the neural lobe have been examined after daily consecutive administration of polyethelene glycol (PEG) and hypertonic NaCl solution to mastromys natalensis.
2. Treatment with PEG and hypertonic saline caused a significant decrease in the total vasopressin content of the neural lobe (187(41 and 255(45 mU. neural lobe respectively) as compared to that of the control value (542(56 mU/neural lobe).
3. The decrease is correlated with the depletion of neurosecretory granules as observed under the electron microscope.
4. An interesting finding relates to the fact that hypovolemia not only stimulates the release of vasopressin but also effects the lipid content of the pituicytes.
5. The present studies are in agreement with the findings of the other workers in mammalian species. However, in this species of animals the activation of volume receptors is more predominent than that of Osmoreceptors.
Source of Support: None, Conflict of Interest: None