| RESEARCH PAPER
|Year : 1985 | Volume
| Issue : 1 | Page : 34-41
Central cholinergic involvement in clonidine and shock induced aggression and its modification by nitrazepam, haloperidol and propranolol: an experimental study in albino rats
K Jain, FSK Barar
1. Clonidine (50 mg/kg ip) induced a peculiar aggressive behavior in mice, associated with drastically reduced ACh level (p < 0.0001) in the whole brain. Footshock also caused significant reduction in ACh level (p < 0.001).
2. Perhaps central cholinoceptive mechanisms are involved in both clonidine and shock- induced aggression (CIA and SIA). Nitrazepam (NTZ), haloperidol (HAL) and propranolol (PROP) reduced the ACh level(s) significantly
3. All the drugs decreased the biting/fighting episodes. However, correlation between the anti-aggressive action and the changes in ACh - lowering effect of CIA and SIA caused by these drugs was absent.
4. Nitrazepam, HAL, AND PROP significantly raised the diminished CIA-induced Ach level (p <0.001), but they potentiated the Ach-lowering effect of SIA. When HAL or PROP administration preceded CIA or SIA, they antagonized the Ach-lowering effect of drug(s) alone.
5. Interestingly NTZ, administered prior to CIA or SIA was fount to be further potentiate (p <0.001) the Ach reduction caused by NTZ alone.
Source of Support: None, Conflict of Interest: None