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Year : 1985  |  Volume : 17  |  Issue : 1  |  Page : 30-33

Effect of multiple doses of diazepam and promethazine on psychomotor performance of human volunteers

Correspondence Address:
P Worlikar

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Source of Support: None, Conflict of Interest: None

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1. Effects of three doses of diazepam (5,10 and 20 mg) and promethazine (10,25 and 50) mg) given orally were studied on psychomotor performance and mental function tests in unrestricted conditions. 2. Both diazepam and promethazine caused dose related increase in the choice reaction time (R.T.) and decreased critical flicker fusion frequency (C.F.F.) in a dose dependent manner, the effects of the former being more pronounced than that of the latter drug on R.T., short term memory (S.T.M.) was depressed by diazepam only. Arithmetic ability (A.A.) and Digital symbol substitution test (D.S.S.T.) proved to be insensitive to the effects of both drugs. 3. Subjectively, volunteers rated 5 mg of diazepam and 10 mg promethazine and 10 mg diazepam and 25 mg promethazine to be equisedative. 4. Subjective rating along the Visual Analogue mood scales (V.A.S.) indicates that volunteers do discriminate between the drugs and their doses along certain scales, (drowsy-alert. tired-active, and depressed-euphoric) but not along other scales (tense-relaxed, anxious-confident).


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