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Year : 1984  |  Volume : 16  |  Issue : 3  |  Page : 132-135

Effect of concurrent use of cimetidine and anti-inflammatory agents in experimental models of peptic ulcer and inflammation

Correspondence Address:
A K Mahajan

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Source of Support: None, Conflict of Interest: None

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1. Cimetidine (20 mg/kg/i.p) inhibited the peptic ulcer-index in histamine treated adult albino rats and afforded a protection of 22% and 23% respectively in hydrocortisone (7.5 mg/kg/i.p) and phenylbutazone (1.5 mg/kg/i.p) pretreated and similarly challenged animals. 2. Hydrocortisone and phenylbutazone in the aforementioned doses significantly inhibited the dextran/carrageenin induced oedema and cotton pellet granuloma. 3. Concurrent use of cimetidine did not significantly affect the antiinflammatory potential of phenylbutazone or hydrocortisone nor did it on its own modify any of the tested phase of inflammation.


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