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Year : 1984  |  Volume : 16  |  Issue : 2  |  Page : 99-101

Activities of glucose 6 phosphate and sorbitol dehydrogenases in alloxan induced cataract: an experimental study

Correspondence Address:
U M Rawal

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Source of Support: None, Conflict of Interest: None

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1. Decrease in the activity of glucose 6 phosphate dehydrogenase (G6PDH), sorbitol dehydrogenase (SDH) and NADP has been suggested as a possible cause of cataract formation, via the effects on glycolysis, HMP shunt and sorbitol pathways in galactosemic and other types of cataract 2. In contrast to normal lenses alloxan-induced cataractous lenses showed a decrease in the activities of G 6 PDH and SDH in blood, aqueous humor and lens. 3. The results indicate that aloxan-induced cataract has an inhibitory effect on some of the lenticubr metabolic pathways.


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