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Year : 1984  |  Volume : 16  |  Issue : 2  |  Page : 96-98

Evidence for inhibitory histamine H2 receptors in the guinea pig ileum

Correspondence Address:
M P Muley

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Source of Support: None, Conflict of Interest: None

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1. Ranitidine, a newly introduced H2 antagonist potentiated the contractile responses of guinea pig ileum to histamine. 2. Histamine could inhibit the contractile responses to acetylcholine when H1 receptors were blocked by pheniramine maleate. 3. When the tone of the guinea pig ileum preparation was increased by continuous superfusion of acetylcholine with HI blocker pheniramine in the perfusate, histamine and dimaprit could produce dose dependent relaxation. This could be blocked by ranitidine. 4. It is suggested that inhibitory-histamine H2 receptors are present in the guinea pig ileum.


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