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Year : 1984  |  Volume : 16  |  Issue : 2  |  Page : 87-91

Compatibility of chandonium iodide, a new neuromuscular Blocking agent with intravenous anaesthetic in cats

Correspondence Address:
Y V Suri

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Source of Support: None, Conflict of Interest: None

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1. Interaction of chandonium iodide, a new non-depolarizing neuromuscular blocking agent, with intravenous anaesthetic agents like thiopentone, ketamine and etomidate has been studied in cats. 2. The onset and duration of neuromuscular block with chandonium and its reversibility by neostigmine were unaffected by the aneasthetic agents investigated. A signifificandy higher dose of chandonium was required with ketamine to produce 50% block of neuromuscular transmission. 3. Chandonium exhibited atropine like effect on cardiac vagal neuroeffector junction. It had no significant effect on blood pH, pCO2 or pO2 . A significant increase ( P < 0.01) in serum potassium was observed in cats anaesthetised with etomidate prior to administration of chandonium and a significant decrease (P < 0.05) was observed with thiopentone anaesthesia.


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