| SHORT COMMUNICATION
|Year : 1984 | Volume
| Issue : 2 | Page : 112-114
Yohimbine prolongs the duration of antinociceptive activity of morphine in mice
AM Ageel, OT Ginawi
1. The effect of intraperitoneal yohimbine on pain threshold in mice has been investigated. The drug was devoid of any analgesic activity at lower doses (1 mg/kg). However, the pain reactions was modified at 10 mg/kg.
2. Subanalgesic doses of yohimbine prolonged the duration of morphine analgesia.
3. Alteration in the ratio of brain 5 HT : Noradrenaline has been proposed as a possible mechanism for the effects of yohimbine.
A M Ageel
Source of Support: None, Conflict of Interest: None