| SHORT COMMUNICATION |
|
| Year : 1984 | Volume
: 16
| Issue : 2 | Page : 112-114 |
Yohimbine prolongs the duration of antinociceptive activity of morphine in mice
AM Ageel, OT Ginawi
Correspondence Address:
A M Ageel
 Source of Support: None, Conflict of Interest: None  | Check |
1. The effect of intraperitoneal yohimbine on pain threshold in mice has been investigated. The drug was devoid of any analgesic activity at lower doses (1 mg/kg). However, the pain reactions was modified at 10 mg/kg.
2. Subanalgesic doses of yohimbine prolonged the duration of morphine analgesia.
3. Alteration in the ratio of brain 5 HT : Noradrenaline has been proposed as a possible mechanism for the effects of yohimbine.
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