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Year : 1983  |  Volume : 15  |  Issue : 4  |  Page : 371-374

Central histaminergic modulation of peripheral inflammation of rats

Correspondence Address:
Das Neeta

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Source of Support: None, Conflict of Interest: None

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The possible modulatory role of the central histaminergic system, in carrageenin induced pedal edema in rats, was investigated by central administration of histamine and histamine antagonists, and then noting their effects on the intensity and time course of the edema. Central administration of histamine significantly inhibited carrageenin-induced pedal inflammation throughout the period of observation. On the contrary, the H1 and H2 receptor antagonists, mepyramine and cimetidine respectively. enhanced the inflammatory response, though the results were statistically significant only with the former. The results have been discussed in the light of reported histaminergic influences on the hypothalamo-pituitary-adrenal axis and consequent increase in endogenous corticosteroid levels.


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