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Year : 1983  |  Volume : 15  |  Issue : 4  |  Page : 361-366

Morphine dependence and withdrawal in rat: role of dopamine

Correspondence Address:
Z Y Khan

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Source of Support: None, Conflict of Interest: None

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Dependence was induced in rats by repeated intraperitoneal injections of morphine sulfate withdrawal signs were precipitated by subcutaneous injection of naloxone. The dopamine agonists, i.e, apomorghine d-amphetamine and I-dopa aggravated the withdrawal signs while synthesis inhibitors / depletors of dopamine, i.e, reserpine and DL-a-methyl-p-tyrosine prevented the occurrence of almost all the withdrawal signs. These findings suggest the involvement of dopamine in the production of morphine dependence and withdrawal.


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