| SHORT COMMUNICATION |
|
| Year : 1983 | Volume
: 15
| Issue : 4 | Page : 361-366 |
Morphine dependence and withdrawal in rat: role of dopamine
ZY Khan, PC Dandiya
Correspondence Address:
Z Y Khan
 Source of Support: None, Conflict of Interest: None  | Check |
Dependence was induced in rats by repeated intraperitoneal injections of morphine sulfate withdrawal signs were precipitated by subcutaneous injection of naloxone. The dopamine agonists, i.e, apomorghine d-amphetamine and I-dopa aggravated the withdrawal signs while synthesis inhibitors / depletors of dopamine, i.e, reserpine and DL-a-methyl-p-tyrosine prevented the occurrence of almost all the withdrawal signs. These findings suggest the involvement of dopamine in the production of morphine dependence and withdrawal.
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