| SHORT COMMUNICATION
|Year : 1983 | Volume
| Issue : 4 | Page : 353-360
Involvement of histaminergic mechanisms in the antagonistic effect of morphine on methamphetamine stereotypy in mice
MP Muley, JJ Balsara, AG Chandorkar
Pretreatmentwith morphine was found to decrease the intensity of methamphetaminc stereotypy in mice.This inhibitory effect of morphine on methamphetamine stereotypy was significantly increased by prior treatment with L-histidine, a precursor of brain histamine, in a dose which per se had no significant effect on methamphetamine stereotypy. Further, pretreatment with chlorcyclizine, a H1 receptor antagonist, not only increased the intensity of methamphetamine stereotypy but also prevented morphine from exerting an inhibitory effect on methamphetamine stereotypy.The results with L-histidine and chlorcyclizine suggest an involvement of central histaminergic mechanisms in the inhibitory effect of morphine on methamphetamine stereotypy in mice.
M P Muley
Source of Support: None, Conflict of Interest: None