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Year : 1983  |  Volume : 15  |  Issue : 4  |  Page : 349-351

Preliminary pharmacological studies on glycosides Symplocus spicata, roxb

Correspondence Address:
Y V Rao

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Source of Support: None, Conflict of Interest: None

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A mixture of two chemically pure glycosides obtained from the stem bark of Symplocos spicata Roxb was studied for pharmacological actions. The glycosides (5 mg/kg, ip) possessed marked relaxant effect (equipotent with the relaxant effect of 10 'g/kg, iv adrenaline) on intestine in situ and transient hypotension in anaesthetised dog and moderate relaxant effect on isolated rabbit ileum. The spasmogenic responses of DMPP and acetyl-choline were attenuated by 40% and 55% respectively on isolated guinea-pig ileum. The glycosides had positive inotropic and chronotropic actions on perfused frog's heart and a weak curare-like activity on isolated frog's rectus abdominis muscle. The glycosides did not have any CNS activity.


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