| SHORT COMMUNICATION
|Year : 1983 | Volume
| Issue : 4 | Page : 349-351
Preliminary pharmacological studies on glycosides Symplocus spicata, roxb
YV Rao, gupta G Das, SB Acharya, NKR Pathak, M Biswas
A mixture of two chemically pure glycosides obtained from the stem bark of Symplocos spicata Roxb was studied for pharmacological actions. The glycosides (5 mg/kg, ip) possessed marked relaxant effect (equipotent with the relaxant effect of 10 'g/kg, iv adrenaline) on intestine in situ and transient hypotension in anaesthetised dog and moderate relaxant effect on isolated rabbit ileum. The spasmogenic responses of DMPP and acetyl-choline were attenuated by 40% and 55% respectively on isolated guinea-pig ileum. The glycosides had positive inotropic and chronotropic actions on perfused frog's heart and a weak curare-like activity on isolated frog's rectus abdominis muscle. The glycosides did not have any CNS activity.
Y V Rao
Source of Support: None, Conflict of Interest: None