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Year : 1983  |  Volume : 15  |  Issue : 4  |  Page : 331-342

Anti-inflammatory and analgesic activities of oleanolic acid 3-/3- Glucoside (RDG-1) from Randia dumetorum (Rubiaceae)

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D Ghosh

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Oleanolic acid 3-/3-Glucoside (RDG-1) was isolated from the seeds of the plant Randia dumetornm (Rubiaceae). The compound showed significant anti-inflammatory activity in the exudative and proliferative phases of inflammation in the doses of 25 and 100 mg/kg orally. Significant analgesia was observed only on thermal stimulus. It did not show any antipyretic activity against Brewer's yeast induced pyrexia in rats.The approximate oral LD50 were found to be 3600 mg/kg and 1500 mg/kg in mice and rats respectively.


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