IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1055 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded128    
    Comments [Add]    

Recommend this journal


Year : 1983  |  Volume : 15  |  Issue : 4  |  Page : 321-330

Studies on interactions of calcium antagonists with cardiotonic agents

Correspondence Address:
D K Basu

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Two calcium antagonists, viz., D-600 (a methoxy derivative of verapamil) and Nisoldipine, were tested for their influence on cardiac activity of frog heart in situ and rabbit atria. The interaction of these agents with the cardiotonic effects produced by the catecholamines, cardiac glycoside and free fatty acid (FFA), was also observed. Both the calcium antagonists exerted a negative cardiotropic effect on heart. They could affectively block the positive chronotropic effect, but not the inotropic effect of the catecholamines, both the positive chronotropic and inotropic effects of free fatty acids, but did not affect in any way the cardiotropic effect of digoxin.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow