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Year : 1983  |  Volume : 15  |  Issue : 3  |  Page : 209-221

Functional significance of mast cells in experimentally produced cryptorchid condition and in cadmium induced testicular necrosis

Correspondence Address:
S R Dasgupta

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Source of Support: None, Conflict of Interest: None

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A single injection of cadmium chloride at a dose level of 0.45 mg/kg resulted in consistent testicular necrosis in albino rats as well as in experimentally produced cryptorchid condition, within 72 h by causing injury to vascular endothelium mediated through steady release of catecholamines. The progressive increment of mast cells (MC) running parallel with the intensity of damage of testis following cadmium intoxication as a cryptorchid, was in record. With the prior treatment of reserpice, ergot or removal of adrenal glands, these changes in the mast cells were not observed. On the basis of histological studies it is suggested that testicular lesion or necrosis following cryptorchid condition or cadmium insulation is partly caused by mast cells.


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