IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 3772 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded88    
    Comments [Add]    

Recommend this journal


Year : 1983  |  Volume : 15  |  Issue : 3  |  Page : 165-170

Effect of L-Dopa, amantadine and tremorine on brain monamines

Correspondence Address:
S D Seth

Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

The effect of L-dopa, alone and in combination, on brain dopamine, norepinephrine, serotonin, 5-hydroxyindole acetic acid and monoamine oxidase activity was investigated in tremorine induced tremor syndrome in rats. L-dopa, alone and in combination with amantadine, produced a remarkable rise in dopamine and 5-hydroxyindole acetic acid and a reduction in serotonin content.Tremorine failed to influence any of the parameters. The findings suggest that L-dopa and amantadine have pro-found effects on brain biogenic amines which may account for the therapeutic effects as well as behavioural side-effects frequently encountered in clinical practice.


Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer | Privacy Notice
Online since 20th July '04
Published by Wolters Kluwer - Medknow