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Year : 1983  |  Volume : 15  |  Issue : 3  |  Page : 153-156

Effect of intravenous and intracerebroventricular administration of tolazoline (priscol) on blood sugar

Correspondence Address:
S S Ainapure

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Source of Support: None, Conflict of Interest: None

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Tolazoline (priscol) an imidazoline. derivative, unlike clonidine, a congener of the same series, produced hypoglycemia when administered by both the intravenous and intracerebroventricular routes in dogs. The drug also lowered the blood sugar levels in rats, increased the deposition of glycogen in the liver and decreased the serum free fatty acid concentrations. The hypoglycemia may be attributed to peripheral utilisation of glucose to glycogen, but a central cholinergic mechanism may also contribute to the same since the centralhypoglycemic effect was blocked by atropine.


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