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Year : 1983  |  Volume : 15  |  Issue : 2  |  Page : 85-89

Cholinesterase enzyme inhibition by some anti-arrhythmic drugs in vitro

Correspondence Address:
M Alkondon

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Source of Support: None, Conflict of Interest: None

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The cbolioesterate (ChE) inhibitory activity of different groups of anti-arrhythmic drugs were investigated in vitro these drugs were found to be more potent in inhibiting the plasma (pseudo) ChE than RBC (true) ChE enzymes. On the basis of the potency as pseudo ChE inhibitor, these drugs could be divided into potent inhibitors like quinidine, UM-272 (the quaternary methyl analogue of propranolol), moderate inhibitors like racemic propranol, chloroquine quinine and procainamide and weak inhibitors like lignocaine, timolol and sotalol, Both racemic propranolol and UM-272 were found to reverse ouabain-induced arrhythmias in dogs where as timolol was found to have no such property. A good correlation exists between the in vitro inhibition of pseudoChE enzyme and the antagonism of ouabin arrhythmias in dogs.


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